Senior/Principal Scientist, Biochemistry

Cambridge, MA
Apr. 2021
New Equilibrium Biosciences discovers drugs that target intrinsically disordered proteins through its integrated computational-experimental platform, with the mission of creating transformative medicines for patients with cancers and neurodegenerative disorders. We are seeking an experimental biochemist with 2+ years of biotech/pharma R&D experience to join our growing team starting in April 2021. You should be comfortable leading scientific projects, working independently and within a team, and managing CROs. Beyond direct technical expertise in protein expression/purification and assay design, you should also be passionate about discovering novel therapeutics through interdisciplinary collaboration.

Required Qualifications

  • Ph.D. in Biochemistry, Molecular Biology, or a related field, with at least 2 years of experience in biotech/pharma (may include postdoctoral research), or M.S. with 5+ years of industry experience
  • Demonstrated impact in a drug discovery setting
  • Experience with resource management and utilizing CROs
  • Significant experience with:
    • Prokaryotic and eukaryotic (insect & mammalian) recombinant protein construct design, expression, and purification
    • Design/Development of enzymatic activity and protein-ligand interaction assays
  • Excellent problem-solving skills for independently developing protocols
  • Positive attitude and a passion for discovering novel therapeutics

Desired Qualifications

  • Experience with any combination of these: 
    • Intrinsically disordered proteins
    • Hit validation, lead optimization, or small molecule MOA studies
    • Cell viability assays
    • High-throughput screening
  • Familiarity with NMR, SPR, ITC, BLI, Fluorescence Spectroscopy, or SAXS
  • Excellent oral and written communication skills, with the ability to contribute to a multidisciplinary team


  • Design and perform experiments as a key member of the drug discovery team in collaboration with biophysical, biological, and computational scientists
  • Express and purify recombinant proteins to support biophysical investigations and drug discovery efforts
  • Manage multiple CROs as appropriate
  • Prepare figures/slides for internal and external presentations
  • Help shape the growth and culture of New Equilibrium Biosciences
If interested, please apply via our google form by March 22nd, 2021. Reach out to careers@newequilibriumbio.com if you have any questions. We look forward to hearing from you!